In early February 2011, Ritter joined the cast of the ABC sitcom Don't Trust the B---- in Apartment 23, playing the title role of Chloe, a New York City party girl and con artist who tries to rip off her new roommates after they move in, but who ends up befriending and "mentoring" one of the applicants. The series was canceled on January 22, 2013 after two seasons. On February 15, 2013, it was reported that Ritter would star as Nora in the NBC comedy pilot Assistance, based on Leslye Headland's play of the same name. However, it was confirmed in January 2014 that the pilot would not be picked up to series. On July 9, 2013, it was announced that Ritter would star in Jake Hoffman's directorial debut, Asthma, which centers on the indie rock scene in New York City. It was announced on February 20, 2014 that Ritter would star on NBC's astronaut-themed comedy pilot Mission Control as aerospace engineer Dr. Mary Kendricks. On October 15, 2014, NBC announced that it was no longer moving forward with the show.