In October 2012, she participated in an Indian reality TV show, Bigg Boss Season 6 as a contestant on the TV Channel Colors. However, she had to make an emergency exit from the Bigg Boss house after spending nearly four weeks due to her father's demise. After leaving the show, she said in an interview with Rediff. com that she accepted the offer to do the show as her father, who had been unwell & was taken care of by Karishma, didn't want her to feel sad and wanted her to get noticed for a better career. After about 15 days of her exit, Karishma re-entered the show on day 42. She told Network 18, "I am feeling quite okay now. This is because of my dad's blessing that Colors has given me another chance to join the show. " She was voted out of the show in December 2012. Reacting about her eviction, she commented in an interview, "I would have definitely liked to stay till the end, but I can't complain. Being able to survive in the house (Bigg Boss show) for 80 odd days isn't a mean feat. " She also said, "I'll remember this experience all my life. It's been very interesting and emotional at the same time. " Karishma made a special appearance on the show later as a presenter on the day before the finale of the show in January 2013.  Talking about the recognition she received at the show, Karsishma told The Times of India, "Work has increased and yes, life has changed in terms of opportunities that are coming my way. It has been one of the toughest emotional journeys for me but it has definitely helped my career. "