On March 7, 2019, Pedroia made his spring training debut, hitting a single in his lone at bat of the game while playing in the field for two innings; it was his first game action since May 2018.  Pedroia began the season on the injured list.  On April 4, he was sent to the Class A Greenville Drive on a rehabilitation assignment, where he played in three games, batting 3-for-9.  Pedroia was activated for Boston's home opener on April 9, appeared in six games while batting 2-for-20 (. 100), and returned to the injured list on April 18 due to left knee irritation.  He began a rehabilitation assignment with Double-A Portland on May 2.  On May 11, he was scratched from a start due to knee discomfort, and his assignment with Portland was halted on May 13.  He restarted his rehabilitation, first with Triple-A Pawtucket on May 17, and then with Double-A Portland on May 24.  Pedroia was removed from Portland's May 25 game due to left knee soreness.  After being evaluated, he announced on May 27 that he was going to take some time to evaluate his future. When asked if he would ever play again, he said "I'm not sure. " The same day, the Red Sox moved Pedroia to the 60-day IL.